Defining the role of biased calcium-sensing receptor signalling in kidney stone disease
Abstract:
Biased signalling via the calcium-sensing receptor (CaSR) may be a common cause of kidney stone disease; this project aims to fully elucidate the effects of kidney-stone associated genetic variants on CaSR-signalling and identify drugs that have the potential to be innovative therapies for kidney stone prevention.
Mail-In canceR dIagnosis and Analysis by Dielectrophoresis - Bladder Cancer (MIRIAD-BC)
Abstract:
We have previously demonstrated that electrical analysis of cells in urine allows diagnosis of bladder cancer; in this study we will develop this technique, optimising sample collection and analysis, identifying methods of tumour grading, and quantify how long samples can last before processing, ahead of a subsequent clinical trial.
Development and validation of Intra-urethral intra-operative pressureDevelopment and validation of Intra-urethral intra-operative pressuremeasurement system for optimal sling tensioning
Abstract:
This project aims to develop and validate a system that can be used to measure pressure along the urethra (waterpipe/bladder outlet) during surgery to treat stress urinary incontinence (SUI, leakage of urine during exercise, cough, sneeze or strain).
Promoting an understanding of pelvic mesh complications: Development and validation of a condition-specific Patient Reported Outcome Measure
Abstract:
The aim of this project is to develop and validate a Patient Reported Outcome Measure (PROM) that can be used to assess pain related to pelvic mesh implants, including following mesh removal procedures.
Sestamibi Kidney for the Assessment of renal Neoplasms (SKAN)
Abstract:
This project aims to evaluate existing and novel diagnostic imaging techniques in the assessment of small renal tumours, with a view to reducing unnecessary invasive diagnostics and management in patients with benign disease.
